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Spdeftm1.2Cle
Targeted Allele Detail
Nomenclature
Symbol: Spdeftm1.2Cle
Name: SAM pointed domain containing ets transcription factor; targeted mutation 1.2, Hans Clevers
MGI ID: MGI:4410321
Gene: Spdef  Location: Chr17:27714352-27728950 bp, - strand  Genetic Position: Chr17, 14.59 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154852
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, flp mediated recombination of Spdeftm1.1Cle removes the neo cassette from the allele, which lacks exon 6. The absence of protein expression was confirmed by immunohistochemistry on colon samples. (J:154852)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spdef Mutation:  6 strains or lines available
References
Original:  J:154852 Gregorieff A, et al., The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology. 2009 Oct;137(4):1333-45.e1-3
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory