Tg(Slc16a8-cre/ERT2,-EGFP)1Moss
Transgene Detail

Summary

• Symbol: Tg(Slc16a8-cre/ERT2,-EGFP)1Moss
• Name: transgene insertion 1, Steven E Moss
• MGI ID: MGI:4399744
• Synonyms: RPE^CreER
• Transgene: Tg(Slc16a8-cre/ERT2,-EGFP)1Moss Location: unknown
• Alliance: Tg(Slc16a8-cre/ERT2,-EGFP)1Moss page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Slc16a8-cre/ERT2,-EGFP)1Moss expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc16a8 (MGI:1929519)

• Mutation details: The transgene was constructed from a modification of BAC RP24-149-K18 such that a cassette containing an improved cre gene fused to the modified human ESR1 receptor (ERT2) and an IRES-EGFP followed by an frt-flanked neo cassette was inserted at the start of the Slc16a8 open reading frame. Transient flp expression in removed the neo cassette in bacterial cells. Cre activity is detected in the retinal pigment epithelium. (J:154671)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc16a8 (mouse) Summary of all recombinase alleles driven by Slc16a8. Comparative matrix view of recombinase activities Alliance mouse Slc16a8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:154671 Longbottom R, et al., Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18728-33
• All: 1 reference(s)