Eomes^tm2.1Rob
Targeted Allele Detail

Summary

• Symbol: Eomes^tm2.1Rob
• Name: eomesodermin; targeted mutation 2.1, Elizabeth J Robertson
• MGI ID: MGI:4399131
• Synonyms: Eomes^GFP, Tbr2GFP
• Gene: Eomes Location: Chr9:118307259-118315176 bp, + strand Genetic Position: Chr9, 70.21 cM, cytoband F3
• Alliance: Eomes^tm2.1Rob page

Eomes^tm1Rob/Eomes^tm2.1Rob Edil3^{Tg(Sox2-cre)1Amc}/0 embryos fail to form the mesoderm cell layer and are blocked in gastrulation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154785
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: An GFP gene and floxed neo cassette replaces 500 bp of the first coding exon. Transient cre expression in ES cells removed the neo cassette. (J:154785)

Generation of the Eomes^tm2.1Rob allele

Expression

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eomes Mutation: 41 strains or lines available

References

• Original: J:154785 Arnold SJ, et al., Generation and analysis of a mouse line harboring GFP in the Eomes/Tbr2 locus. Genesis. 2009 Nov;47(11):775-81
• All: 13 reference(s)