Gcg^tm1Yhys
Targeted Allele Detail

Summary

• Symbol: Gcg^tm1Yhys
• Name: glucagon; targeted mutation 1, Yoshitaka Hayashi
• MGI ID: MGI:4399066
• Synonyms: Gcg^gfp
• Gene: Gcg Location: Chr2:62304874-62313994 bp, - strand Genetic Position: Chr2, 35.85 cM
• Alliance: Gcg^tm1Yhys page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154694
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence spanning exon 2 through part of intron 3 was replaced with GFP and a neo cassette. The absence of transcript expression was confirmed by northern blot on pancreatic extracts. (J:154694)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gcg Mutation: 32 strains or lines available

References

• Original: J:154694 Hayashi Y, et al., Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells. Mol Endocrinol. 2009 Dec;23(12):1990-9
• All: 14 reference(s)