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Lhx2tm1.1Ddmo
Targeted Allele Detail
Nomenclature
Symbol: Lhx2tm1.1Ddmo
Name: LIM homeobox protein 2; targeted mutation 1.1, Dennis D M OLeary
MGI ID: MGI:4399043
Synonyms: Lhx2fl, Lhx2loxP
Gene: Lhx2  Location: Chr2:38339281-38369733 bp, + strand  Genetic Position: Chr2, 24.31 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154611
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 1 and an additional loxP site was inserted downstream of exon 3. Germ line, flp mediated recombination removed the neo cassette leaving exons 1 through 3 floxed. (J:154611)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx2 Mutation:  8 strains or lines available
References
Original:  J:154611 Chou SJ, et al., Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat Neurosci. 2009 Nov;12(11):1381-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory