Lhx2^tm1.1Ddmo
Targeted Allele Detail

Summary

• Symbol: Lhx2^tm1.1Ddmo
• Name: LIM homeobox protein 2; targeted mutation 1.1, Dennis D M OLeary
• MGI ID: MGI:4399043
• Synonyms: Lhx2^fl, Lhx2^loxP
• Gene: Lhx2 Location: Chr2:38229293-38259745 bp, + strand Genetic Position: Chr2, 24.31 cM, cytoband B
• Alliance: Lhx2^tm1.1Ddmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154611
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 1 and an additional loxP site was inserted downstream of exon 3. Germ line, flp mediated recombination removed the neo cassette leaving exons 1 through 3 floxed. (J:154611)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx2 Mutation: 12 strains or lines available

References

• Original: J:154611 Chou SJ, et al., Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat Neurosci. 2009 Nov;12(11):1381-9
• All: 8 reference(s)