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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, The Netherlands Cancer Institute
MGI ID: MGI:4398910
Synonyms: Bmi1LSL, Bmi-CTS, Gt(ROSA)26Sortm1(CMV-Bmi1,-EGFP)Nki
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Pituitary tumor in Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+ Tg(Gfap-cre)2Brn/0 mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:184533
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe targeting construct contains a CAG promoter, a floxed transcriptional stop cassette [PGK promoter neo triple poly A] followed by a cDNA encoding mouse Bmi1 and a downstream ires-eGFP cassette. Conditional excision of the poly A signals results in expression of the two inserted constructs under the control of the CAG promoter. (J:184533)
Generation of the Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki allele
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  291 strains or lines available
Original:  J:184533 Nacerddine K, et al., Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest. 2012 May 1;122(5):1920-32
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory