Spdeftm1.1Cle
Targeted Allele Detail
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Symbol: |
Spdeftm1.1Cle |
Name: |
SAM pointed domain containing ets transcription factor; targeted mutation 1.1, Hans Clevers |
MGI ID: |
MGI:4398888 |
Gene: |
Spdef Location: Chr17:27933326-27947929 bp, - strand Genetic Position: Chr17, 14.59 cM, cytoband B1
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Alliance: |
Spdeftm1.1Cle page
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Absence of mucous (goblet) cells in tracheal and laryngeal submucosal glands in Spdeftm1.1Cle/Spdeftm1.1Cle mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:154852
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Parent Cell Line: |
IB10/E14IB10 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 6 and an additional loxP site was inserted downstream of exon 6. Germ line, cre mediated recombination removed exon 6 leaving the frt flanked neo cassette intact.
(J:154852)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Spdef Mutation: |
15 strains or lines available
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Original: |
J:154852 Gregorieff A, et al., The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology. 2009 Oct;137(4):1333-45.e1-3 |
All: |
4 reference(s) |
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