Cd3g^tm1.1Cage
Targeted Allele Detail

Summary

• Symbol: Cd3g^tm1.1Cage
• Name: CD3 antigen, gamma polypeptide; targeted mutation 1.1, Carsten Geisler
• MGI ID: MGI:4398866
• Synonyms: Cd3gamma^LLAA
• Gene: Cd3g Location: Chr9:44880870-44891729 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Cd3g^tm1.1Cage page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142387
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 5 was replaced with one in which nucleotide substitutions result in the amino acid substitutions of alanine for leucine at positions 131 and 132 (L131A, L132A). A floxed hygro cassete inserted upstream of the modified exon 5 was removed by germ line, cre mediated recombination. The substitutions occur within the di-leucine motif. (J:142387)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd3g Mutation: 24 strains or lines available

References

• Original: J:142387 Bonefeld CM, et al., TCR down-regulation controls virus-specific CD8+ T cell responses. J Immunol. 2008 Dec 1;181(11):7786-99
• All: 3 reference(s)