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Cd3gtm1.1Cage
Targeted Allele Detail
Nomenclature
Symbol: Cd3gtm1.1Cage
Name: CD3 antigen, gamma polypeptide; targeted mutation 1.1, Carsten Geisler
MGI ID: MGI:4398866
Synonyms: Cd3gammaLLAA
Gene: Cd3g  Location: Chr9:44969572-44980431 bp, - strand  Genetic Position: Chr9, 24.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142387
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 5 was replaced with one in which nucleotide substitutions result in the amino acid substitutions of alanine for leucine at positions 131 and 132 (L131A, L132A). A floxed hygro cassete inserted upstream of the modified exon 5 was removed by germ line, cre mediated recombination. The substitutions occur within the di-leucine motif. (J:142387)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd3g Mutation:  8 strains or lines available
References
Original:  J:142387 Bonefeld CM, et al., TCR down-regulation controls virus-specific CD8+ T cell responses. J Immunol. 2008 Dec 1;181(11):7786-99
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory