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Camk2gtm1.1Irt
Targeted Allele Detail
Nomenclature
Symbol: Camk2gtm1.1Irt
Name: calcium/calmodulin-dependent protein kinase II gamma; targeted mutation 1.1, Ira Tabas
MGI ID: MGI:4398829
Gene: Camk2g  Location: Chr14:20734875-20794088 bp, - strand  Genetic Position: Chr14, 11.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154647
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination removes exon 1 and 2. Exon 2 encodes part of the catalytic domain including the ATP binding motif essential for kinase function. The absence of protein expression was confirmed by western blot analysis of macrophage extracts. (J:154647)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Camk2g Mutation:  14 strains or lines available
References
Original:  J:154647 Timmins JM, et al., Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest. 2009 Oct;119(10):2925-41
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory