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Skiltm1.1Kluo
Targeted Allele Detail
Nomenclature
Symbol: Skiltm1.1Kluo
Name: SKI-like; targeted mutation 1, Kunxin Luo
MGI ID: MGI:4398740
Synonyms: SnoNm
Gene: Skil  Location: Chr3:31095058-31122577 bp, + strand  Genetic Position: Chr3, 15.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154718
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 1 was replaced with a modified exon 1 in which the codons corresponding to the residues 85 through 88 (the R-Smad binding site) and 266 through 267 (the Co-Smad binding site) were altered to code for alanines. A floxed neo cassette was inserted downsteam of the modified exon 1 and subsequently removed by germ line, cre mediated recombination. This allele is predicted to produce a protein product incapable of interacting with R-Smads and Smad4. (J:154718)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Skil Mutation:  18 strains or lines available
References
Original:  J:154718 Pan D, et al., SnoN functions as a tumour suppressor by inducing premature senescence. EMBO J. 2009 Nov 18;28(22):3500-13
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory