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Khktm2Dtb
Targeted Allele Detail
Nomenclature
Symbol: Khktm2Dtb
Name: ketohexokinase; targeted mutation 2, David T Bonthron
MGI ID: MGI:4398729
Synonyms: KHK-A/C KO, Khkdelta
Gene: Khk  Location: Chr5:30921436-30931248 bp, + strand  Genetic Position: Chr5, 16.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154144
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA stop codon was introduced into exon 3a preventing the production of the A transcript. A floxed neo cassette was inserted upstream of the modified exon 3a. Exons 4 through 6 and part of 7 were deleted, preventing the production of the C splice variant. Western blot analysis confirmed the absence of isoforms A and C. (J:154144, J:166959)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Khk Mutation:  13 strains or lines available
References
Original:  J:154144 Diggle CP, et al., Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem. 2009 Aug;57(8):763-74
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory