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GldcGt(EUCG0001d02)Hmgu
Gene trapped Allele Detail
Nomenclature
Symbol: GldcGt(EUCG0001d02)Hmgu
Name: glycine decarboxylase; gene trap EUCG0001d02, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4380899
Synonyms: GldcGT1
Gene: Gldc  Location: Chr19:30098447-30175429 bp, - strand  Genetic Position: Chr19, 24.87 cM, cytoband C
Mutation
origin
Mutant Cell Line:  EUCG0001d02
Germline Transmission:  Earliest citation of germline transmission: J:221782
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector     Vector: rsFlipROSAbgeo*
 
Mutation detailsA gene trap vector consisting of long terminal repeats flanking a construct with pairs of FRT, F3, loxP and lox5171 sites surrounding a splice acceptor-neo-polyA cassette was inserted in intron 2. qRT-PCR analysis indicates that mRNA is diminished by 80-90% in homozygotes, indicating this is a strong hypomorphic allele. (J:221782)
Sequence Tags: 
Sequence tag details (2 tags)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gldc Mutation:  6 strains or lines available
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory