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Ahi1tm1Jgg
Targeted Allele Detail
Nomenclature
Symbol: Ahi1tm1Jgg
Name: Abelson helper integration site 1; targeted mutation 1, Joseph G Gleeson
MGI ID: MGI:4367773
Gene: Ahi1  Location: Chr10:20952547-21080429 bp, + strand  Genetic Position: Chr10, 9.75 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154321
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 6 and a floxed neo cassette was inserted downstream of exon 7. Cre-mediated recombination removed exon 6 and 7 and the neo cassette. The lack of protein expression was confirmed by western blot analysis on brain extracts. (J:158019)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ahi1 Mutation:  13 strains or lines available
References
Original:  J:154321 Lancaster MA, et al., Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med. 2009 Sep;15(9):1046-54
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory