About   Help   FAQ
Myd88tm1Jcbr
Targeted Allele Detail
Nomenclature
Symbol: Myd88tm1Jcbr
Name: myeloid differentiation primary response gene 88; targeted mutation 1, Jens Bruning
MGI ID: MGI:4367063
Synonyms: Myd88lox
Gene: Myd88  Location: Chr9:119335988-119340040 bp, - strand  Genetic Position: Chr9, 71.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153664
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 5. (J:153664)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myd88 Mutation:  40 strains or lines available
References
Original:  J:153664 Kleinridders A, et al., MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 2009 Oct;10(4):249-59
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory