About   Help   FAQ
Sh3tc2tm1.1Rchr
Targeted Allele Detail
Nomenclature
Symbol: Sh3tc2tm1.1Rchr
Name: SH3 domain and tetratricopeptide repeats 2; targeted mutation 1.1, Roman Chrast
MGI ID: MGI:4367025
Synonyms: Sh3tc2deltaEx1
Gene: Sh3tc2  Location: Chr18:61952928-62015719 bp, + strand  Genetic Position: Chr18, 34.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153705
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with EGFP and a floxed neo cassette. Germ line, cre mediated recombination removes the neo cassette. (J:153705)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh3tc2 Mutation:  43 strains or lines available
References
Original:  J:153705 Arnaud E, et al., SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17528-33
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/05/2019
MGI 6.14
The Jackson Laboratory