Bcl2l11tm2.1Boui
Targeted Allele Detail
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Symbol: |
Bcl2l11tm2.1Boui |
Name: |
BCL2 like 11; targeted mutation 2.1, Philippe Bouillet |
MGI ID: |
MGI:4366751 |
Synonyms: |
BimN, BimNoxa |
Gene: |
Bcl2l11 Location: Chr2:127967958-128004467 bp, + strand Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
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Alliance: |
Bcl2l11tm2.1Boui page
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BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:153846
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The BH3 domain (in exon 5) was replaced by the mouse Pmaip1 (Noxa) BH3 domain by site-directed mutagenesis using PCR. A loxP-PGKneo-loxP cassette was inserted 840 bp downstream of exon 5. The neo cassette was removed by crossing the mice to cre deleter transgenic mice.
(J:153846)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Bcl2l11 Mutation: |
32 strains or lines available
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Original: |
J:153846 Merino D, et al., The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol. 2009 Aug 10;186(3):355-62 |
All: |
3 reference(s) |
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