Tg(Camk2a-App*,-Apbb1)25Spim
Transgene Detail
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Symbol: |
Tg(Camk2a-App*,-Apbb1)25Spim |
Name: |
transgene insertion 25, Sanjay W Pimplikar |
MGI ID: |
MGI:4366527 |
Synonyms: |
FeCgamma.25 |
Transgene: |
Tg(Camk2a-App*,-Apbb1)25Spim Location: unknown
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Strain of Origin: |
C57BL/6 |
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Camk2a-App*,-Apbb1)25Spim expresses
2 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
Rat |
Apbb1 (29722) |
Apbb1 |
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Mouse |
App |
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The gene encodes a 59 residue long COOH-terminal fragment. |
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Mutation details: This bigenic transgene line contains the intracellular domain of App and rat Apbb1 both driven by the mouse Camk2a promoter to achieve forebrain and hippocampal expression. Four lines were created (only lines 12 and 25 were named) that express both cDNAs. Line 25 was selected as the representative line.
(J:102815)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:102815 Ryan KA, et al., Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol. 2005 Oct 24;171(2):327-35 |
All: |
5 reference(s) |
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