Tg(Camk2a-App*,-Apbb1)25Spim
Transgene Detail

Nomenclature

Symbol:	Tg(Camk2a-App*,-Apbb1)25Spim
Name:	transgene insertion 25, Sanjay W Pimplikar
MGI ID:	MGI:4366527
Synonyms:	FeCgamma.25
Transgene:	Tg(Camk2a-App*,-Apbb1)25Spim  Location: unknown

Transgene origin

Strain of Origin:

C57BL/6

Transgene description

Transgene Type: 

Transgenic (Inserted expressed sequence)

Mutation: 

Insertion

Tg(Camk2a-App*,-Apbb1)25Spim expresses 2 genes

Transgene expresses:

Organism	Expressed Gene	Homolog in Mouse	Note
Rat	Apbb1 (29722)	Apbb1
Mouse	App		The gene encodes a 59 residue long COOH-terminal fragment.

Mutation details: This bigenic transgene line contains the intracellular domain of App and rat Apbb1 both driven by the mouse Camk2a promoter to achieve forebrain and hippocampal expression. Four lines were created (only lines 12 and 25 were named) that express both cDNAs. Line 25 was selected as the representative line. (J:102815)

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

References

Original:	J:102815 Ryan KA, et al., Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol. 2005 Oct 24;171(2):327-35
All:	5 reference(s)