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Tg(Camk2a-App*,-Apbb1)25Spim
Transgene Detail
Nomenclature
Symbol: Tg(Camk2a-App*,-Apbb1)25Spim
Name: transgene insertion 25, Sanjay W Pimplikar
MGI ID: MGI:4366527
Synonyms: FeCgamma.25
Transgene: Tg(Camk2a-App*,-Apbb1)25Spim  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Camk2a-App*,-Apbb1)25Spim expresses 2 genes
 
Mutation detailsThis bigenic transgene line contains the intracellular domain of App and rat Apbb1 both driven by the mouse Camk2a promoter to achieve forebrain and hippocampal expression. Four lines were created (only lines 12 and 25 were named) that express both cDNAs. Line 25 was selected as the representative line. (J:102815)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:102815 Ryan KA, et al., Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol. 2005 Oct 24;171(2):327-35
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory