Dnm1l^tm1.2Hise
Targeted Allele Detail

Summary

• Symbol: Dnm1l^tm1.2Hise
• Name: dynamin 1-like; targeted mutation 1.2, Hiromi Sesaki
• MGI ID: MGI:4366511
• Synonyms: Drp1^-
• Gene: Dnm1l Location: Chr16:16130094-16176823 bp, - strand Genetic Position: Chr16, 10.12 cM
• Alliance: Dnm1l^tm1.2Hise page

Small size and internal hemorrhage in Dnm1l^tm1.2Hise/Dnm1l^tm1.2Hise embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153835
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Germ line, cre mediated recombiantion removed exons 3 through 5. The absence of protein expression was confirmed by western blot analysis compared with embryo extracts. (J:153835)

Generation of the Dnm1l^tm1.1Hise and Dnm1l^tm1.2Hise alleles

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnm1l Mutation: 43 strains or lines available

References

• Original: J:153835 Wakabayashi J, et al., The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol. 2009 Sep 21;186(6):805-16
• All: 12 reference(s)