About   Help   FAQ
Targeted Allele Detail
Symbol: Lrpap1tm1Vln
Name: low density lipoprotein receptor-related protein associated protein 1; targeted mutation 1, Fred Van Leuven
MGI ID: MGI:4366260
Synonyms: RAP-
Gene: Lrpap1  Location: Chr5:35091501-35105766 bp, - strand  Genetic Position: Chr5, 18.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:107547
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe last 68 bp of exon 6 and part of intron 6 was replaced with a PGK hygromycin B selection cassette. Northern blot analysis demonstrated only an abbreviated 1.6 kb mRNA. Western blot analysis failed to detect full lenght protein. A less than 30 kDa protein was found in kidneys but not elswhere. (J:107547)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrpap1 Mutation:  17 strains or lines available
Original:  J:107547 Umans L, et al., Analysis of expression of genes involved in apolipoprotein E-based lipoprotein metabolism in pregnant mice deficient in the receptor-associated protein, the low density lipoprotein receptor, or apolipoprotein E. Biol Reprod. 1999 Nov;61(5):1216-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory