About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Targeted Allele Detail
Symbol: Pkd1tm3.1Bol
Name: polycystin 1, transient receptor poteintial channel interacting; targeted mutation 3.1, Alessandra Boletta
MGI ID: MGI:4366014
Synonyms: Pkd1Myc
Gene: Pkd1  Location: Chr17:24549950-24596514 bp, + strand  Genetic Position: Chr17, 12.4 cM
Hydrocephalus in Pkd1tm2.2Bol/Pkd1tm3.1Bol Tg(Nes-cre)1Kln/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:153606
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 45 and a myc tag, a loxP site, an HA tag, and an frt flanked neo cassette were inserted downstream of exon 46. Germ line, flp mediated recombination removed the neo cassette leaving exons 45 and 46 floxed. (J:153606)
Generation of the Pkd1tm3.1Bol and Pkd1tm3.2Bol alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:  99 strains or lines available
Original:  J:153606 Wodarczyk C, et al., A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One. 2009;4(9):e7137
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory