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Pkd1tm3.1Bol
Targeted Allele Detail
Nomenclature
Symbol: Pkd1tm3.1Bol
Name: polycystin 1, transient receptor poteintial channel interacting; targeted mutation 3.1, Alessandra Boletta
MGI ID: MGI:4366014
Synonyms: Pkd1Myc
Gene: Pkd1  Location: Chr17:24549950-24596514 bp, + strand  Genetic Position: Chr17, 12.4 cM
Hydrocephalus in Pkd1tm2.2Bol/Pkd1tm3.1Bol Tg(Nes-cre)1Kln/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153606
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 45 and a myc tag, a loxP site, an HA tag, and an frt flanked neo cassette were inserted downstream of exon 46. Germ line, flp mediated recombination removed the neo cassette leaving exons 45 and 46 floxed. (J:153606)
Generation of the Pkd1tm3.1Bol and Pkd1tm3.2Bol alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:  99 strains or lines available
References
Original:  J:153606 Wodarczyk C, et al., A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One. 2009;4(9):e7137
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory