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Transgene Detail
Symbol: Tg(Vim*R113C)1Tmm
Name: transgene insertion 1, Thomas M Magin
MGI ID: MGI:4365636
Synonyms: Vim R113C
Transgene: Tg(Vim*R113C)1Tmm  Location: unknown  
Strain of Origin:  CBA
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Vim*R113C)1Tmm expresses 1 gene
Mutation detailsAn 18 kb segment containing 10.5 kb of 5'- and 1 kb of 3'-regulatory sequence was isolated from a BALB/c cosmid library. The myc epitope was introduced by site-directed mutagenesis after serine at the second amino acid position.An additional mutation was introduced by site-directed mutagenesis that resulted in an arginine to cytosine change at amino acid residue 113. The transgenic mouse line was generated from a founder animal expressing the mutant at sub-stoichiometric level (<=30%) compared with the endogenous gene. (J:145782, J:153496)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:145782 Bornheim R, et al., A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice. J Cell Sci. 2008 Nov 15;121(Pt 22):3737-46
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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