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Rnf128tm1.1Flv
Targeted Allele Detail
Nomenclature
Symbol: Rnf128tm1.1Flv
Name: ring finger protein 128; targeted mutation 1.1, Richard Flavell
MGI ID: MGI:4365554
Synonyms: GRAIL-
Gene: Rnf128  Location: ChrX:138464089-138573894 bp, + strand  Genetic Position: ChrX, 61.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153216
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked neomycin cassette was placed in intron 6 and a third loxP site was placed in intron 3. Cre mediated recombination removed exons 4 through 6. This deletion results in a out of frame mutation. The absence of protein expression was confirmed by western blot on spleen, thymus, kidney, liver, and brain extracts. (J:153216)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rnf128 Mutation:  10 strains or lines available
References
Original:  J:153216 Kriegel MA, et al., E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16770-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory