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Targeted Allele Detail
Symbol: Mapk6tm1Melo
Name: mitogen-activated protein kinase 6; targeted mutation 1, Sylvain Meloche
MGI ID: MGI:4365549
Synonyms: Erk-, Erk3-, Mapk6LacZNeo
Gene: Mapk6  Location: Chr9:75386782-75410016 bp, - strand  Genetic Position: Chr9, 42.3 cM, cytoband E1
Mapk6tm1Melo/Mapk6tm1Melo mice display cyanosis, carpoptosis, smaller body weight, and neonatal lethality

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:153218
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2, 3, and 4 were replaced with a lacZ gene and neo cassette via homologous recombination. Quantitative RT-PCR and western blot analysis confirmed the absence of expression in lungs from homozygous mutants and homozygous MEFs, respectively. (J:153218)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk6 Mutation:  12 strains or lines available
Original:  J:153218 Klinger S, et al., Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16710-5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory