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Ptpn11tm1.2Wbm
Targeted Allele Detail
Summary
Symbol: Ptpn11tm1.2Wbm
Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1.2, Walter Birchmeier
MGI ID: MGI:4365540
Synonyms: Ptpn11tm1.2Cbm, Shp2delta
Gene: Ptpn11  Location: Chr5:121268596-121329460 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Alliance: Ptpn11tm1.2Wbm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153219
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Germ line, cre mediated recombination removed exon 3 and 4. (J:153219)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:  43 strains or lines available
References
Original:  J:153219 Grossmann KS, et al., The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16704-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory