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Targeted Allele Detail
Symbol: Xbp1tm1Tiw
Name: X-box binding protein 1; targeted mutation 1, Takao Iwawaki
MGI ID: MGI:4365400
Synonyms: XBP1-
Gene: Xbp1  Location: Chr11:5470659-5475893 bp, + strand  Genetic Position: Chr11, 3.61 cM
Germline Transmission:  Earliest citation of germline transmission: J:153222
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette replaced exons 2 - 4 via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in homozygous MEFs. (J:153222)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xbp1 Mutation:  19 strains or lines available
Original:  J:153222 Iwawaki T, et al., Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory