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Targeted Allele Detail
Symbol: Cdsntm1.1Ics
Name: corneodesmosin; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:4365388
Synonyms: Cdsnfl
Gene: Cdsn  Location: Chr17:35552128-35557180 bp, + strand  Genetic Position: Chr17, 18.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:153292
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2 and a second loxP site and frt flanked neo cassette were inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:153292)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdsn Mutation:  7 strains or lines available
Original:  J:153292 Leclerc EA, et al., Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction. J Cell Sci. 2009 Aug 1;122(Pt 15):2699-709
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory