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Wastm2Itl
Targeted Allele Detail
Summary
Symbol: Wastm2Itl
Name: Wiskott-Aldrich syndrome; targeted mutation 2, inGenious Targeting Laboratory
MGI ID: MGI:4362085
Synonyms: Wastm2Igl, WasY293F
Gene: Was  Location: ChrX:7947705-7956730 bp, - strand  Genetic Position: ChrX, 3.65 cM
Alliance: Wastm2Itl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153247
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Single point mutation
 
Mutation detailsAn frt and loxP flanked neo cassette was inserted downstream of exon 7. Exon 9 was replaced with one in which a point mutation (TAC->TTC) results in the amino acid substitution of phenylalanine for tyrosine at position 293 (Y293F). This allele contains a phospho-dead mutation. (J:153247)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Was Mutation:  11 strains or lines available
References
Original:  J:153247 Blundell MP, et al., Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15738-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory