Tg(Pomc-cre)1Lowl
Transgene Detail

Summary

• Symbol: Tg(Pomc-cre)1Lowl
• Name: transgene insertion 1, Bradford B Lowell
• MGI ID: MGI:4362028
• Synonyms: Pomc-cre, Pomc-Cre(BAC2), Tg(Pomc-cre)1Stl
• Transgene: Tg(Pomc-cre)1Lowl Location: unknown
• Alliance: Tg(Pomc-cre)1Lowl page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pomc-cre)1Lowl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pomc (MGI:97742)

• Mutation details: A Pomc (pro-opiomelanocortin-alpha) (bacterial artificial chromosome; RPCI22-372J15) was used to generate mice expressing cre under the control of the Pomc promoter. The cre recombinase cDNA was inserted via homologous recombination into the first ATG transcription start site, ablating the first 30bp of the POMC coding sequence. This transgenic vector was introduced to FVB-derived embryos. (J:106354, J:122763)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pomc (mouse) Summary of all recombinase alleles driven by Pomc. Comparative matrix view of recombinase activities Alliance mouse Pomc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:122763 McHugh TJ, et al., Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science. 2007 Jul 6;317(5834):94-9
• All: 67 reference(s)