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Targeted Allele Detail
Symbol: Tbx22tm1.1Sta
Name: T-box 22; targeted mutation 1.1, Philip Stanier
MGI ID: MGI:4361267
Synonyms: Tbx22null, Tbx22tm1.1(b-actin/Dexon0-2/NEO)Sta
Gene: Tbx22  Location: ChrX:107667964-107688978 bp, + strand  Genetic Position: ChrX, 47.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:153100
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first three exons, including the start codon, the N-terminal repression domain, nuclear localization signal and part of the T-box domain was deleted upon cre mediated recombination. A neomycin resistance cassette was inserted in the intron after the third exon. (J:153100)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx22 Mutation:  3 strains or lines available
Original:  J:153100 Pauws E, et al., Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Hum Mol Genet. 2009 Nov 1;18(21):4171-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory