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Targeted Allele Detail
Symbol: Tbx22tm1.1Sta
Name: T-box 22; targeted mutation 1.1, Philip Stanier
MGI ID: MGI:4361267
Synonyms: Tbx22null, Tbx22tm1.1(b-actin/Dexon0-2/NEO)Sta
Gene: Tbx22  Location: ChrX:107667964-107688978 bp, + strand  Genetic Position: ChrX, 47.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:153100
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first three exons, including the start codon, the N-terminal repression domain, nuclear localization signal and part of the T-box domain was deleted upon cre mediated recombination. A neomycin resistance cassette was inserted in the intron after the third exon. (J:153100)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx22 Mutation:  2 strains or lines available
Original:  J:153100 Pauws E, et al., Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Hum Mol Genet. 2009 Nov 1;18(21):4171-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory