St14^tm3Bug
Targeted Allele Detail

Summary

• Symbol: St14^tm3Bug
• Name: suppression of tumorigenicity 14 (colon carcinoma); targeted mutation 3, Thomas H Bugge
• MGI ID: MGI:4361197
• Synonyms: St14^fl, St14^LoxP
• Gene: St14 Location: Chr9:31000698-31043149 bp, - strand Genetic Position: Chr9, 16.61 cM
• Alliance: St14^tm3Bug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153070
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette with a 3' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. (J:153070)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St14 Mutation: 44 strains or lines available

References

• Original: J:153070 List K, et al., Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol. 2009 Oct;175(4):1453-63
• All: 4 reference(s)