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Tg(Eno2-ATN1)14Tx
Transgene Detail
Nomenclature
Symbol: Tg(Eno2-ATN1)14Tx
Name: transgene insertion 14, Tian Xu
MGI ID: MGI:4360673
Synonyms: Atro-118Q14
Transgene: Tg(Eno2-ATN1)14Tx  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J x SJL/J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Eno2-ATN1)14Tx expresses 1 gene
 
Mutation detailsThe transgene comprises a cDNA encoding full length human ATN1 containing a 118 residue polyglutamine tract, encoded by 118 CAG repeats, inserted into a transgenic vector containing the rat neuron-specific enolase promoter. This transgenic line carries two copies of the construct and, as shown by immunohistology and western blot analyses, expresses human ATN1 protein in the brain. (J:112706)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:112706 Ying M, et al., Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. J Biol Chem. 2006 May 5;281(18):12580-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory