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Tg(Eno2-ATN1)3Tx
Transgene Detail
Summary
Symbol: Tg(Eno2-ATN1)3Tx
Name: transgene insertion 3, Tian Xu
MGI ID: MGI:4360669
Synonyms: Atro-118Q3
Transgene: Tg(Eno2-ATN1)3Tx  Location: unknown  
Alliance: Tg(Eno2-ATN1)3Tx page
Transgene
origin
Strain of Origin:  C57BL/6J x SJL/J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Eno2-ATN1)3Tx expresses 1 gene
 
Mutation detailsThe transgene comprises a cDNA encoding full length human ATN1 containing a 118 residue polyglutamine tract, encoded by 118 CAG repeats, inserted into a transgenic vector containing the rat neuron-specific enolase promoter. This transgenic line carries one copy of the construct and, as shown by immunohistology and western blot analyses, expresses human ATN1 protein in the brain. (J:112706)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:112706 Ying M, et al., Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. J Biol Chem. 2006 May 5;281(18):12580-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory