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Apctm2Rfo
Targeted Allele Detail
Nomenclature
Symbol: Apctm2Rfo
Name: APC, WNT signaling pathway regulator; targeted mutation 2, Riccardo Fodde
MGI ID: MGI:4360657
Synonyms: Apc1572T
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Mammary adenocarcinomas from Apctm2Rfo/Apc+ mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151494
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsA hygro resistance cassette was inserted at a site corresponding to codon 1572. This mutation is predicted to result in a truncated protein. (J:151494)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  59 strains or lines available
References
Original:  J:151494 Gaspar C, et al., A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PLoS Genet. 2009 Jul;5(7):e1000547
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory