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Targeted Allele Detail
Symbol: Wnk4tm2.1Suc
Name: WNK lysine deficient protein kinase 4; targeted mutation 2.1, Shinichi Uchida
MGI ID: MGI:4360633
Synonyms: WNK4deltaEx7-8
Gene: Wnk4  Location: Chr11:101260567-101277409 bp, + strand  Genetic Position: Chr11, 64.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:152915
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGerm line, cre mediated recombination removed exon 7 and the neo cassette. Western blot analysis confirmed the production of two protein products from alternative spliced transcripts that fuses exon 6 to exon 8 (63 KDa) or exon 6 to exon 9 (49 KDa). Authors state that this is a hypomorphic allele. (J:152915)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnk4 Mutation:  28 strains or lines available
Original:  J:152915 Ohta A, et al., Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009 Oct 15;18(20):3978-86
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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