Mapk8ip1^tm2.1Rjd
Targeted Allele Detail

Summary

• Symbol: Mapk8ip1^tm2.1Rjd
• Name: mitogen-activated protein kinase 8 interacting protein 1; targeted mutation 2.1, Roger J Davis
• MGI ID: MGI:4360022
• Synonyms: Jip1^S59N
• Gene: Mapk8ip1 Location: Chr2:92214021-92231608 bp, - strand Genetic Position: Chr2, 50.99 cM, cytoband E1
• Alliance: Mapk8ip1^tm2.1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152617
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 contained a point mutation that resulted in the amino acid substitution of asparagine for serine at position 59 (S59N). A floxed neo cassette was inserted downsteam of the modified exon 2 was removed by cre mediated recombination. (J:152617)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk8ip1 Mutation: 33 strains or lines available

References

• Original: J:152617 Standen CL, et al., Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes. Mol Cell Biol. 2009 Sep;29(17):4831-40
• All: 1 reference(s)