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Hprt1tm5(RCAN1-lacZ)Aird
Targeted Allele Detail
Summary
Symbol: Hprt1tm5(RCAN1-lacZ)Aird
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 5, William C Aird
MGI ID: MGI:4359808
Synonyms: DSCR-1s-lacZ, DSCR1s-lacZ, DSCR-1s-lacZ-Hprt
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm5(RCAN1-lacZ)Aird page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152536
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details-1,664/+83 of the promoter region for the short variant of human DSCR1 (Rcan1) was used to drive expression of a lacZ reporter gene within the Hprt locus. The promoter and start region for the Hprt locus was included in the 3' end of the construct to correct an endogenous defect in the ES cells. The reporter gene was uniformly expressed in the endothelium of heterozygote embryos but was down-regulated postnatally. Reporter gene expression was detected in a subset of endothelial cells in adult brain, heart, lung, and kidney. (J:152536)
Generation of the Hprt1tm5(RCAN1-lacZ)Aird allele
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1272 strains or lines available
References
Original:  J:152536 Minami T, et al., The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Invest. 2009 Aug;119(8):2257-70
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory