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Ccr6tm1.1Jmf
Targeted Allele Detail
Nomenclature
Symbol: Ccr6tm1.1Jmf
Name: chemokine (C-C motif) receptor 6; targeted mutation 1.1 Joshua M Farber
MGI ID: MGI:4359772
Gene: Ccr6  Location: Chr17:8236043-8257141 bp, + strand  Genetic Position: Chr17, 4.9 cM, cytoband A1
Ccr6tm1.1Jmf/Ccr6tm1.1Jmf mice are resisant to IL23-induced acanthosis and dermal inflammation

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152716
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting cassette consisting of an EGFP downstream of an internal ribosome entry site and a floxed neomycin resistance gene replaced positions 3094-3611 in the open reading frame of the gene. The neomycin cassette was subsequently removed by crossing chimera mice with transgenic mice expressing cre recombinase in the germline. Gene inactivation was confirmed by flow cytometry analysis of activated, homozygote B cells. Low levels of GFP expression were detected in activated B cells but not in other activated lymphocytes suggesting reporter gene expression does not recapitulate expression of the endogenous locus. (J:152716)
Generation of the Ccr6tm1.1Jmf allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccr6 Mutation:  20 strains or lines available
References
Original:  J:152716 Hedrick MN, et al., CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J Clin Invest. 2009 Aug;119(8):2317-29
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory