Dp(7Herc2-Mkrn3)1Taku
Targeted Allele Detail
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Symbol: |
Dp(7Herc2-Mkrn3)1Taku |
Name: |
duplication, Chr 7, Toru Takumi 1 |
MGI ID: |
MGI:4359729 |
Synonyms: |
15q Dup, Dp |
Gene: |
Dp(7Herc2-Mkrn3)1Taku Location: Chr7:55699944-62069887 bp Genetic Position: Chr7, Syntenic
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Allele Type: |
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Targeted |
Mutation: |
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Duplication
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Dp(7Herc2-Mkrn3)1Taku involves 291 genes/genome features (Gm22466, Gm23873, Gm23490 ...)
View all
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Mutation details: Sequential rounds of targeting inserted the selection cassettes and loxP sites proximal to Herc2 and distal to Mkrn3. A double-targeted clone in which the targeting had occurred on the homologous chromosomes (trans) was transiently transfected with a Cre recombinase in ES cells to induce recombination between the loxP sites on opposite chromosomes, which generated clones with a balanced duplication and deletion of 6.3 Mb region between Herc2 and Mkrn3. Only duplicated allele can be recovered after meiosis and mating.
(J:151648)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Carrying any Dp(7Herc2-Mkrn3)1Taku Mutation: |
1 strain or line available
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Original: |
J:151648 Nakatani J, et al., Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell. 2009 Jun 26;137(7):1235-46 |
All: |
17 reference(s) |
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