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Targeted Allele Detail
Symbol: Dp(7Herc2-Mkrn3)1Taku
Name: duplication, Chr 7, Toru Takumi 1
MGI ID: MGI:4359729
Synonyms: Dp
Gene: Dp(7Herc2-Mkrn3)1Taku  Location: Chr7:56050196-62420139 bp  Genetic Position: Chr7, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:151648
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted
Mutation:    Duplication
  Dp(7Herc2-Mkrn3)1Taku involves 293 genes/genome features (Gm30295, Gm30404, Gm31858 ...) View all
Mutation detailsSequential rounds of targeting inserted the selection cassettes and loxP sites proximal to Herc2 and distal to Mkrn3. A double-targeted clone in which the targeting had occurred on the homologous chromosomes (trans) was transiently transfected with a Cre recombinase in ES cells to induce recombination between the loxP sites on opposite chromosomes, which generated clones with a balanced duplication and deletion of 6.3 Mb region between Herc2 and Mkrn3. Only duplicated allele can be recovered after meiosis and mating. (J:151648)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(7Herc2-Mkrn3)1Taku Mutation:  1 strain or line available
Original:  J:151648 Nakatani J, et al., Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell. 2009 Jun 26;137(7):1235-46
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory