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QTL Variant Detail
QTL variant: Mom5C57BL/6J
Name: modifier of Min 5; C57BL/6J
MGI ID: MGI:4359615
Synonyms: Mom5C57BL/6
QTL: Mom5  Location: Chr5:8797672-33318293 bp  Genetic Position: Chr5, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
Mutation detailsThe C57BL/6J allele at this locus is recessive to the 129P2/OlaHsd regarding its effect on intestinal adenoma number when inherited in conjunction with ApcMin. 15 of 144 known genes located within this QTL region are polymorphic between 129P2/OlaHsd and C57BL/6J. (J:152194)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


A Genetic linkage experiment was carried out to determine if there was a genetic modifier affected the number of intestinal tumors in Apc(min/+) mice. 129P2/OlaHsd (- /Erb) knockout mice were backcrossed to C57BL/6J - Apc(Min/+) mice for 10 generations (N10). At both N5 and N10 Erb(+/-) females were intercrossed with Apc(Min/+) males. Using STS markers linkage was analyzed at N5 whereby 10 of the intercross mice with the fewest intestinal adenomas were mated to 10 with the most intestinal adenomas. A more robust explanation of the linkage cross is reported in the methods section for this cross. The 1.5 LOD support interval ranges from D5Mit48 to D5Mit388 with a peak at D5Mit348. The QTL in this region is defined as Mom5 with Rint1 suggested as a strong candidate

Original:  J:152194 Oikarinen SI, et al., Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis. Carcinogenesis. 2009 Sep;30(9):1591-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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