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Transgene Detail
Symbol: Tg(Prnp-TARDBP*A315T)95Balo
Name: transgene insertion 95, Robert Baloh
MGI ID: MGI:4358722
Synonyms: Prp-TDP43A315T, Prp-TDP43A315T, Prp-TDP43-A315T
Transgene: Tg(Prnp-TARDBP*A315T)95Balo  Location: unknown  Genetic Position: Chr9, Syntenic
Alliance: Tg(Prnp-TARDBP*A315T)95Balo page
Strain of Origin:  C57BL/6 x CBA
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Prnp-TARDBP*A315T)95Balo expresses 1 gene
Mutation detailsThe construct contains the full-length human TAR DNA binding protein (TARDBP or TDP-43) cDNA sequence that was modified to harbor an N-terminal Flag tag immediately after the start methionine and the A315T amino acid substitution associated with familial ALS inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene. A single Prp-TDP43A315T founder line was established (founder line 95) mapping to two close but distinct sites on Chr 9: Chr9:38,417,354 and Chr9:38,405,898 (coordinates from MGSC ver 37, mm9). (J:153197)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:153197 Wegorzewska I, et al., TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18809-14
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory