Tg(KRT5-cre/ERT2)1Blh
Transgene Detail
|
Symbol: |
Tg(KRT5-cre/ERT2)1Blh |
Name: |
transgene insertion 1, Brigid L Hogan |
MGI ID: |
MGI:4358332 |
Synonyms: |
CK5-CreERT2, KRT5-CreERT2 |
Transgene: |
Tg(KRT5-cre/ERT2)1Blh Location: unknown
|
Alliance: |
Tg(KRT5-cre/ERT2)1Blh page
|
|
Strain of Origin: |
Not Specified
|
|
Transgene Type: |
|
Transgenic (Inducible, Recombinase) |
Inducer: |
|
tamoxifen |
Mutation: |
|
Insertion
|
|
|
Tg(KRT5-cre/ERT2)1Blh expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
KRT5 (3852) |
|
|
|
|
|
Mutation details: The 6-kb human keratin 5 (KRT5) promoter drives a cre/ERT2 cassette. The cre/ERT2 is flanked by an intron and a polyadenylation sequence from the pCI mammalian expression vector. The construct was injected into fertilized zygotes. 11 founder lines were obtained, and 1 line that gave robust recombination in tracheal basal cells was propagated and maintained on a C57BL/6 x C3H background.
(J:152012)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
KRT5
(human)
|
|
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:152012 Rock JR, et al., Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12771-5 |
All: |
28 reference(s) |
|