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Npr2pwe
Spontaneous Allele Detail
Nomenclature
Symbol: Npr2pwe
Name: natriuretic peptide receptor 2; peewee
MGI ID: MGI:4358115
Gene: Npr2  Location: Chr4:43631935-43651244 bp, + strand  Genetic Position: Chr4, 23.05 cM
Mutation
origin
Strain of Origin:  NAW
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
  Npr2pwe involves 1 genes/genome features (Npr2) View all
 
Mutation detailsThe peewee mutation is a 4 base pair deletion that alters codon 313 from leucine to a premature stop (L313X) in exon 3 within the ligand binding domain. The truncated protein is predicted to be nonfunctional. (J:188839)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr2 Mutation:  9 strains or lines available
References
Original:  J:105913 Moran JL, et al., Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res. 2006 Mar;16(3):436-40
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory