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Terf1tm1.1Blas
Targeted Allele Detail
Summary
Symbol: Terf1tm1.1Blas
Name: telomeric repeat binding factor 1; targeted mutation 1.1, Maria A Blasco
MGI ID: MGI:4357772
Synonyms: TRF1flox
Gene: Terf1  Location: Chr1:15875870-15914276 bp, + strand  Genetic Position: Chr1, 4.88 cM, cytoband E3
Alliance: Terf1tm1.1Blas page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152077
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in the 5'UTR and an frt flanked neo cassette with a 5' loxP site was inserted into intron 1. Germ line, flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:152077)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Terf1tm1.1Blas
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Terf1 Mutation:  35 strains or lines available
References
Original:  J:152077 Martinez P, et al., Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev. 2009 Sep 1;23(17):2060-75
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory