Tg(Vav1-NUP98/HOXD13)C1Apla
Transgene Detail

Summary

• Symbol: Tg(Vav1-NUP98/HOXD13)C1Apla
• Name: transgene insertion C1, Peter Aplan
• MGI ID: MGI:4357688
• Synonyms: NHD13 tg
• Transgene: Tg(Vav1-NUP98/HOXD13)C1Apla Location: unknown
• Alliance: Tg(Vav1-NUP98/HOXD13)C1Apla page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vav1-NUP98/HOXD13)C1Apla expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HOXD13 (3239)

  Hoxd13

  (MGI:96205)

  human

  NUP98 (4928)

  Nup98

  (MGI:109404)

• Mutation details: A transgenic construct containing cDNA of the amino-terminal region of the human nucleoporin 98kDa (NUP98) fused to the homeodomain of the human homeobox D13 (HOXD13) under the control of the 3' and 5' mouse vav 1 oncogene (Vav1) regulatory elements and SV40 polyadenylation site sequence was injected into fertilized FVB/N mouse eggs. Five founders were obtained but only 1 line, C1, transmitted the transgene. Founder line C1 was subsequently established. Expression is detected in hematopoietic tissues, such as thymus, spleen, and bone marrow, but not is nonhematopoietic tissues like brain, kidney, and liver. (J:107446)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:107446 Lin YW, et al., NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood. 2005 Jul 1;106(1):287-95
• All: 21 reference(s)