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Transgene Detail
Symbol: Tg(Vav1-NUP98/HOXD13)C1Apla
Name: transgene insertion C1, Peter Aplan
MGI ID: MGI:4357688
Synonyms: NHD13 tg
Transgene: Tg(Vav1-NUP98/HOXD13)C1Apla  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Vav1-NUP98/HOXD13)C1Apla expresses 2 genes
Mutation detailsA transgenic construct containing cDNA of the amino-terminal region of the human nucleoporin 98kDa (NUP98) fused to the homeodomain of the human homeobox D13 (HOXD13) under the control of the 3' and 5' mouse vav 1 oncogene (Vav1) regulatory elements and SV40 polyadenylation site sequence was injected into fertilized FVB/N mouse eggs. FIve founders were obtained but only 1 line, C1, transmitted the transgene. Founder line C1 was subsequently established. Expression is detected in hematopoietic tissues, such as thymus, spleen, and bone marrow, but not is nonhematopoietic tissues like brain, kidney, and liver. (J:107446)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:107446 Lin YW, et al., NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood. 2005 Jul 1;106(1):287-95
All:  10 reference(s)

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