About   Help   FAQ
Tg(Vav1-NUP98/HOXD13)C1Apla
Transgene Detail
Nomenclature
Symbol: Tg(Vav1-NUP98/HOXD13)C1Apla
Name: transgene insertion C1, Peter Aplan
MGI ID: MGI:4357688
Synonyms: NHD13 tg
Transgene: Tg(Vav1-NUP98/HOXD13)C1Apla  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Vav1-NUP98/HOXD13)C1Apla expresses 2 genes
 
Mutation detailsA transgenic construct containing cDNA of the amino-terminal region of the human nucleoporin 98kDa (NUP98) fused to the homeodomain of the human homeobox D13 (HOXD13) under the control of the 3' and 5' mouse vav 1 oncogene (Vav1) regulatory elements and SV40 polyadenylation site sequence was injected into fertilized FVB/N mouse eggs. FIve founders were obtained but only 1 line, C1, transmitted the transgene. Founder line C1 was subsequently established. Expression is detected in hematopoietic tissues, such as thymus, spleen, and bone marrow, but not is nonhematopoietic tissues like brain, kidney, and liver. (J:107446)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:107446 Lin YW, et al., NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood. 2005 Jul 1;106(1):287-95
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory