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Targeted Allele Detail
Symbol: Ccdc86tm1Hfuj
Name: coiled-coil domain containing 86; targeted mutation 1, Hodaka Fujii
MGI ID: MGI:4356276
Synonyms: CyclonEN
Gene: Ccdc86  Location: Chr19:10941481-10949266 bp, - strand  Genetic Position: Chr19, 7.41 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:151722
Parent Cell Line:  iTL IC1 (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn EGFP cassette and a neomycin resistance gene were placed immediately downstream of ATG start site located in exon 1 of the gene. Correct targeting was confirmed by Southern blotting. Activated lymphocytes from heterozygote mice had 3-fold reduced levels of endogenous gene product compared to controls as determined by quantitative PCR. (J:151722)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccdc86 Mutation:  8 strains or lines available
Original:  J:151722 Saint Fleur S, et al., Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood. 2009 Aug 13;114(7):1355-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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