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Targeted Allele Detail
Symbol: Epn2tm1Ocr
Name: epsin 2; targeted mutation 1, Ottavio Cremona
MGI ID: MGI:4356016
Gene: Epn2  Location: Chr11:61517249-61579687 bp, - strand  Genetic Position: Chr11, 37.96 cM, cytoband B2
Major developmental defects in Epn1tm1Ocr/Epn1tm1Ocr Epn2tm1Ocr/Epn2tm1Ocr embryos

Show the 7 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:151951
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe 3' end of the first coding exon and the 5'end of the following intron were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in multiple tissues from homozygous mice. (J:151951)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epn2 Mutation:  49 strains or lines available
Original:  J:151951 Chen H, et al., Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13838-43
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory