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Ccl2tm1.1Tyos
Targeted Allele Detail
Nomenclature
Symbol: Ccl2tm1.1Tyos
Name: chemokine (C-C motif) ligand 2; targeted mutation 1.1, Teizo Yoshimura
MGI ID: MGI:4355946
Synonyms: MCP-1delta
Gene: Ccl2  Location: Chr11:82035571-82037453 bp, + strand  Genetic Position: Chr11, 49.82 cM, cytoband C-E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151874
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsMice containing the floxed Ccl2 allele were crossed with EIIa-Cre mice to obtain mice lacking exons 1 and 2. Correct targeting was confirmed by Southern blotting. Supernatant analysis of activated homozygote macrophages did not detect protein product confirming this is a null allele. Similar ELISA analysis demonstrated an increase in MCP-3 secretion, which is encoded by the nearby Ccl7 gene. (J:151874)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ccl2 Mutation:  12 strains or lines available
References
Original:  J:151874 Takahashi M, et al., Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. J Immunol. 2009 Sep 1;183(5):3463-71
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory