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Etv6tm1(RUNX1)Haho
Targeted Allele Detail
Nomenclature
Symbol: Etv6tm1(RUNX1)Haho
Name: ets variant 6; targeted mutation 1, Hanno Hock
MGI ID: MGI:4355899
Synonyms: TEL-AML1
Gene: Etv6  Location: Chr6:134035700-134270158 bp, + strand  Genetic Position: Chr6, 64.58 cM, cytoband G2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151639
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6 and 7 were replaced with a floxed neo, floxed STOP, and human RUNX1 coding region. When the floxed neo and STOP cassette are removed by cre-mediated recombination, a fusion product of mouse Etv6 and human RUNX1 (or TEL-AML1) was created. (J:151639)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Etv6 Mutation:  123 strains or lines available
References
Original:  J:151639 Schindler JW, et al., TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 2009 Jul 2;5(1):43-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory