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Tg(tetO-Ifng)184Pop
Transgene Detail
Nomenclature
Symbol: Tg(tetO-Ifng)184Pop
Name: transgene insertion 184, Brian Popko
MGI ID: MGI:4355871
Synonyms: line 184 TRE/IFNg, line 184 TRE/IFN-g, line 184 TRE/IFN-gamma, TRE/IFN-gamma 184, TRE/IFN-gamma line 184
Transgene: Tg(tetO-Ifng)184Pop  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-Ifng)184Pop expresses 1 gene
 
Mutation detailsThe TRE/IFN-gamma transgene was designed with the PhCMV*-1 tetracycline-responsive promoter upstream of a mouse IFN-g cDNA sequence. The PhCMV*-1 tetracycline-responsive promoter contains the human cytomegalovirus (hCMV) minimal promoter fused to the tet-operator (tetO; TRE). The IFN-g cDNA is flanked by 40 bp of 5' and 57 bp of 3' UTR sequences and includes the translation start and stop signals. The sequences that confer IFN-g mRNA instability have been eliminated from the IFN-g cDNA sequence in an effort to increase steady-state mRNA levels derived from the transgene. This 2.3 kb transgene was microinjected into fertilized B6D2F1 oocytes. Founder line 184 was established. (J:94092)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:94092 Lin W, et al., Interferon-gamma induced medulloblastoma in the developing cerebellum. J Neurosci. 2004 Nov 10;24(45):10074-83
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory